Francesco Vito Mandarino

Dr. Francesco Vito Mandarino is a gastroenterologist at the Gastroenterology and Digestive Endoscopy Unit of IRCCS Ospedale San Raffaele.

He graduated in Medicine and Surgery from the University of Bologna in 2016 and specialized in Digestive System Diseases in 2022 at Vita-Salute San Raffaele University.

Between April 2023 and July 2024, he completed a prestigious Clinical and Research Fellowship in Advanced Digestive Endoscopy at Westmead Hospital in Sydney (Australia), one of the world’s most renowned centers for advanced endoscopy, under the supervision of Prof. Michael Bourke, one of the leading global experts in the endoscopic treatment of colorectal polyps. In 2025, he obtained a PhD in Molecular Medicine at Vita-Salute San Raffaele University, with a project dedicated to the molecular and clinical characterization of gastroparesis.

Dr. Mandarino performs diagnostic and operative endoscopic procedures throughout the digestive system, both elective and emergency. The conditions treated include:

• Colorectal polyps: advanced management of difficult and complex lesions through techniques such as Endoscopic Mucosal Resection (EMR) and Endoscopic Submucosal Dissection (ESD).
• Duodenal polyps: endoscopic removal of both neoplastic and non-neoplastic lesions using approaches that minimize the risk of complications while maintaining high success rates.
• Zenker’s diverticulum: endoscopic myotomy.
• Gastroparesis: use of advanced techniques such as Gastric Peroral Endoscopic Myotomy (G-POEM) to significantly improve symptoms and quality of life in patients with refractory gastroparesis.
• Esophageal achalasia: endoscopic treatment through Peroral Endoscopic Myotomy (POEM).
• Barrett’s esophagus: advanced management, including pre-cancerous and cancerous lesions, through resective treatments (EMR, ESD) and ablative techniques such as radiofrequency ablation (RFA).

From a scientific perspective, he focuses on advanced endoscopic techniques for the removal of complex polyps, third-space techniques for the treatment of motility disorders, “painless” sedation during digestive endoscopy, and the treatment of gastroparesis.

He is author and co-author of scientific articles published in international journals and regularly participates in national and international congresses and conferences. He is a member of the Italian Society of Digestive Endoscopy (SIED) and the European Society of Gastrointestinal Endoscopy (ESGE), actively contributing to the development of international guidelines. He is also involved in numerous working groups dedicated to clinical and translational research projects at both national and international levels.