Francesco Vito Mandarino

Dr. Francesco Vito Mandarino is the Head of the Digestive Endoscopy Functional Unit at IRCCS San Raffaele Hospital.

He graduated in Medicine and Surgery from the University of Bologna in 2016 and completed his specialization in Diseases of the Digestive System in 2022 at Vita-Salute San Raffaele University.

Between April 2023 and July 2024, he completed a prestigious Clinical and Research Fellowship in Advanced Digestive Endoscopy at Westmead Hospital in Sydney (Australia), one of the world's leading centers for advanced endoscopy, under the supervision of Professor Michael Bourke, one of the foremost international experts in the endoscopic treatment of colorectal polyps. In 2025, he obtained a PhD in Molecular Medicine from Vita-Salute San Raffaele University.

Since June 1, 2026, he has served as Head of the Digestive Endoscopy Functional Unit.

Dr. Mandarino performs diagnostic and therapeutic endoscopic procedures throughout the digestive tract. The conditions he treats include:

• Colorectal polyps: advanced management of difficult and complex lesions through techniques such as Endoscopic Mucosal Resection (EMR) and Endoscopic Submucosal Dissection (ESD);
• Duodenal polyps: endoscopic removal of both neoplastic and non-neoplastic lesions using approaches designed to minimize complications while maintaining high success rates;
• Zenker’s diverticulum: endoscopic myotomy;
• Gastroparesis: use of advanced techniques such as Gastric Peroral Endoscopic Myotomy (G-POEM) to significantly improve symptoms and quality of life in patients with gastroparesis;
• Esophageal achalasia: endoscopic treatment through Peroral Endoscopic Myotomy (POEM);
• Barrett’s esophagus: advanced management, including precancerous and cancerous lesions, through resective treatments (EMR, ESD) and ablative therapies such as Radiofrequency Ablation (RFA).

From a scientific perspective, his areas of interest include:

• Advanced endoscopic techniques for the removal of complex polyps;
• Third-space endoscopic techniques for the treatment of motility disorders;
• “Pain-free” sedation during digestive endoscopy;
• Treatment of gastroparesis.

He is the author and co-author of scientific articles published in international journals and regularly participates in national and international congresses and conferences.