Carlo Pappone - To make an appointment - GSD - a group of clinics in Italy

Biography

Professor Carlo Pappone is Head of the Clinical Arrhythmology Unit and Electrophysiology Laboratory at IRCCS Policlinico San Donato in Milan. He is also a cardiologist, arrhythmologist and electrophysiologist at Casa di Cura La Madonnina. He is Full Professor of Cardiology at Università Vita-Salute San Raffaele.

In 1986, he graduated in Medicine and Surgery from the Federico II University of Naples, where he specialised in Cardiology four years later. In 1995, he obtained a PhD in Cardiovascular Diseases from the University of Rome Tor Vergata.

Professor Pappone performs all electrophysiological procedures, with particular interest in transcatheter ablation of atrial fibrillation, supraventricular tachycardias and Wolff-Parkinson-White syndrome (WPW), in both adult and paediatric patients.

In scientific research, he focuses on developing new therapeutic strategies for patients with atrial fibrillation and WPW and on preventing sudden arrhythmic death in congenital arrhythmogenic heart diseases.

More recently, his main area of interest has shifted towards the prevention of sudden death and the treatment of ventricular arrhythmias in patients with Brugada syndrome. He developed a new epicardial ablation procedure to identify and eliminate the mechanisms that trigger sudden death in these patients: to date, approximately 600 patients have been successfully treated.

An invited speaker and moderator at major national and international congresses in cardiology and arrhythmology, he is the author of 184 scientific articles, more than 30 book chapters and 184 presentations (16,814 citations, H-index 50).

He is a reviewer for numerous journals, including New England Journal of Medicine, Lancet, Annals of Internal Medicine, Journal of the American College of Cardiology, JAMA, Circulation, European Heart Journal, American Heart Journal, American Journal of Cardiology, Circulation Arrhythmia Electrophysiology, Europace, Heart Rhythm, Journal of the American Medical Association, Journal of Cardiovascular Electrophysiology, Journal of Cardiovascular Medicine, Giornale Italiano di Cardiologia and Giornale Italiano di Aritmologia e Cardiostimolazione.

In 2006, he received the Elite Reviewer Award from the Editorial Board of the Journal of the American College of Cardiology (JACC). He is a Fellow of numerous international cardiology societies, including the American Heart Association (AHA), European Society of Cardiology (ESC) and American College of Cardiology (ACC).

Education

University of Naples Federico II
Degree in Medicine - 1986

Publications

Latest publications

Assessing the Malignant Ventricular Arrhythmic Substrate in Patients With Brugada Syndrome

J Am Coll Cardiol. 2018 Apr 17;71(15):1631-1646. doi: 10.1016/j.jacc.2018.02.022. PMID: 29650119

Pappone C, Ciconte G, Manguso F, Vicedomini G, Mecarocci V, Conti M, Giannelli L, Pozzi P, Borrelli V, Menicanti L, Calovic Z, Della Ratta G, Brugada J, Santinelli V.

Electrical Substrate Elimination in 135 Consecutive Patients With Brugada Syndrome.

Circulation Arrhythmia Electrophysiology. 2017(5):e005053. doi: 10.1161/CIRCEP.117.005053

Pappone C, Brugada J, Vicedomini G, Ciconte G, Manguso F, Saviano M, Vitale R, Cuko A, Giannelli L, Calovic Z, Conti M, Pozzi P, Natalizia A, Crisà S, Borrelli V, Brugada R, Sarquella- Brugada G, Guazzi M, Frigiola A, Menicanti L, Santinelli V.

Brugada Syndrome Phenotype Elimination by Epicardial Substrate Ablation

Circulation Arrhythmia Electrophysiology. 2015 Dec;8(6):1373-81

Brugada J, Pappone C (both first Authors), Berruezo A, Vicedomini G, Manguso F, Ciconte G, Giannelli L, Santinelli V.

Wolff-Parkinson-White syndrome in the era of catheter ablation: insights from a registry study of 2169 patients

Circulation. 2014 Sep 2;130(10):811-9

Pappone C, Vicedomini G, Manguso F, Saviano M, Baldi M, Pappone A, Ciaccio C, Giannelli L, Ionescu B, Petretta A, Vitale R, Cuko A, Calovic Z, Fundaliotis A, Moscatiello M, Tavazzi L, Santinelli V.

Risk of Malignant Arrhythmias in Initially Symptomatic Patients with WPW Syndrome: Results of a Prospective Long-Term Electrophysiological Follow-Up Study

Circulation. 2012 ;125:661-8

Pappone C, Vicedomini G, Manguso F, Baldi M, Pappone A, Petretta A, Vitale R, Saviano M, Ciaccio C, Giannelli L, Calovic Z, Tavazzi L, Santinelli V.

ThermoCool AF Trial Investigators. Comparison of antiarrhythmic drug therapy and radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation: a randomized controlled trial

JAMA 2010; 303:333-40

Wilber DJ, Pappone C, Neuzil P, De Paola A, Marchlinski F, Natale A, Macle L, Daoud EG, Calkins H, Hall B, Reddy V, Augello G, Reynolds MR, Vinekar C, Liu CY, Berry SM, Berry DA;

The natural history of asymptomatic ventricular preexcitation. A long-term prospective follow-up study of 184 asymptomatic children

J Am Coll Cardiol. 2009; 53: 275-280

Santinelli V, Radinovic A, Manguso F, Vicedomini G, Gulletta S, G Paglino, Mazzone P, Ciconte G, Sacchi S, Sala S, Pappone C.

New-onset atrial fibrillation as first clinical manifestation of latent Brugada syndrome. Prevalence and clinical significance.

Eur. Heart J. 2009; 30: 2985-92.

Pappone C, Radinovic A, Manguso F, Vicedomini G, Sala S, Sacco FM, Ciconte G, Saviano M, Ferrari M, Sommariva E, Sacchi S, Ciaccio C, Santinelli V.

Robotic Magnetic Navigation for Atrial Fibrillation Ablation.

J Am Coll Cardiol. 2006 Apr 7;47 (7): 1390-400

Pappone C, Vicedomini G, Manguso F, Mazzone P, Gugliotta F, Sala S, Sora N, Paglino G, Gulletta S, Ciaccio C, Tortoriello V, Del Torchio S, Santinelli V.

Circumferential pulmonary vein ablation for chronic atrial fibrillation: a randomized, controlled study.

The New Engl J Med 2006 2;354:934-94.

Oral H, Pappone C (both, first Authors), Chugh A, Good E, Bogun F, Pelosi F, Bates E , Lehmann M, Vicedomini G, Augello G, Agricola E, Sala S, Santinelli V, Morady F.