Roberta Messina

Roberta Messina
Profession:
Neurologist
Languages:
EN
IT

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Biography

Dr. Roberta Messina is Head of the Headache and Facial Pain Center at the Neurology Unit of IRCCS Ospedale San Raffaele, directed by Prof. Massimo Filippi.

After graduating with honors in Medicine and Surgery from Vita-Salute San Raffaele University in 2011, she specialized in Neurology at the same university, obtaining her Neurology degree in 2018 (grade: 70/70 with honors).

During her specialization, she worked for 18 months at the Headache Center of King’s College London, where she deepened her knowledge and expertise in the diagnosis and treatment of headaches and facial pain.

Her clinical activity mainly focuses on the diagnosis and treatment of primary headaches, such as migraine, tension-type headache, and cluster headache, secondary headaches, and facial pain disorders, including trigeminal neuralgia. She is involved in numerous clinical trials evaluating the efficacy and safety of new therapies for migraine prevention.

After specialization, she undertook a PhD program in Experimental Neurology at Vita-Salute San Raffaele University, where she currently carries out research activity as a researcher.

During her career, she gained experience at two major international headache centers: the Headache Center at King’s College London and the Danish Headache Center in Copenhagen.

Her research activity is focused on studying the pathophysiological mechanisms of migraine and headaches through advanced magnetic resonance imaging techniques, with the aim of improving the understanding of the processes underlying the disease. She was awarded a ministerial grant for the development of one of these projects.

At the same time, she studies acute and preventive migraine therapies, with particular attention to the optimization of therapeutic pathways.

She has participated in numerous research projects in collaboration with national and international groups.

In 2024, she received the Enrico Greppi Award, a prestigious recognition granted within the major scientific societies dedicated to headaches.

She is the author of numerous publications in indexed international scientific journals and book chapters. She is a member of the Editorial Board of The Journal of Headache and Pain and Neurology, serves as a reviewer for numerous scientific journals, and is a member of the Educational Committee of the International Headache Society and of the Scientific Committee of the Italian Neurological Association for Headache Research.

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Publications

Latest publications

Imaging the brain and vascular reactions to headache treatments: a systematic review
J Headache Pain. 2023 May 24;24(1):58.
Messina R, Christensen RH, Cetta I, Ashina M, Filippi M.
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Safety and tolerability of monoclonal antibodies targeting the CGRP pathway and gepants in migraine prevention: A systematic review and network meta-analysis.
Cephalalgia. 2023 Mar;43(3):3331024231152169.
Messina R, Huessler EM, Puledda F, Haghdoost F, Lebedeva ER, Diener HC.
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Biomarkers of Migraine and Cluster Headache: Differences and Similarities
Ann Neurol. 2023 Apr;93(4):729-742.
Messina R, Sudre CH, Wei DY, Filippi M, Ourselin S, Goadsby PJ.
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Functional MRI in migraine
Curr Opin Neurol. 2022 Jun 1;35(3):328-335.
Messina R, Gollion C, Christensen RH, Amin FM.
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Tracking the evolution of non-headache symptoms through the migraine attack
J Headache Pain. 2022 Nov 23;23(1):149.
Messina R, Cetta I, Colombo B, Filippi M.
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Italian Migraine Registry study group. Predictors of response to anti-CGRP monoclonal antibodies: a 24-week, multicenter, prospective study on 864 migraine patients
J Headache Pain. 2022 Nov 1;23(1):138. Link a Pubmed:
Barbanti P, Egeo G, Aurilia C, Altamura C, d'Onofrio F, Finocchi C, Albanese M, Aguggia M, Rao R, Zucco M, Frediani F, Filippi M, Messina R, Cevoli S, Carnevale A, Fiorentini G, Messina S, Bono F, Torelli P, Proietti S, Bonassi S, Vernieri F;
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Clinical correlates of hypothalamic functional changes in migraine patients
Cephalalgia. 2022 Apr;42(4-5):279-290.
Messina R, Rocca MA, Valsasina P, Misci P, Filippi M.
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Tension-type headache
Nat Rev Dis Primers. 2021 Mar 25;7(1):24.
Ashina S, Mitsikostas D, Lee MJ, Yamani N, Wang SJ, Messina R, Ashina H, Buse D, Pozo-Rosich P, Jensen R, Diener HC, Lipton R.
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Discontinuing monoclonal antibodies targeting CGRP pathway after one-year treatment: an observational longitudinal cohort study
J Headache Pain. 2021 Dec 18;22(1):154.
Vernieri F, Brunelli N, Messina R, Costa CM, Colombo B, Torelli P, Quintana S, Cevoli S, Favoni V, d'Onofrio F, Egeo G, Rao R, Filippi M, Barbanti P, Altamura C.
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Candesartan in migraine prevention: results from a retrospective real-world study
J Neurol. 2020 Nov;267(11):3243-3247.
Messina R, Lastarria Perez CP, Filippi M, Goadsby PJ.
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The chronic migraine brain: What have we learned from neuroimaging?
Front Neurol. 2020 Jan 9; 10:1356.
Filippi M and Messina R.
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Dysregulation of multisensory processing stands out from an earyl stage of migraine: a study in pediatric patients
J Neurol. 2020 Mar;267(3):760-769.
Messina R, Rocca MA, Colombo B, Valsasina P, Meani A, Falini A, Filippi M.
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Gray matter volume modifications in migraine: A cross-sectional and longitudinal study
Neurology. 2018 Jul 17;91(3):e280-e292.
Messina R, Rocca MA, Colombo B, Pagani E, Falini A, Goadsby PJ, Filippi M.
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CGRP - a target for acute therapy in migraine: Clinical data
Cephalalgia. 2019 Mar;39(3):420-427.
Messina R and Goadsby PJ.
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Cortical abnormalities in patients with migraine: a surface-based analysis
Radiology 2013; 268: 170-180.
Messina R, Rocca MA, Colombo B, Valsasina P, Horsfield MA, Copetti M, Falini A, Comi G, Filippi M.
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Unveiling Resting-State Functional Connectivity Patterns in Patients With Migraine: A REFORM Study
Neurology. 2026 Mar 10;106(5):e214656. doi: 10.1212/WNL.0000000000214656.
Messina R, Christensen RH, Ashina H, Sankar A, Gollion C, Al-Khazali HM, Filippi M, Ashina M.
The effect of erenumab on brain network function in episodic migraine patients: a randomized, placebo-controlled clinical trial (RESET BRAIN)
J Neurol. 2023 Nov;270(11):5600-5612. doi: 10.1007/s00415-023-11879-9.
Filippi M, Messina R, Bartezaghi M, Cetta I, Colombo B, Grazzi L, Martinelli D, Ornello R, Pichiecchio A, Raimondi D, Russo A, Sacco S, Splendiani A, Tassorelli C, Turrini R, Valsasina P, Rocca MA; RESET BRAIN Study Group.
Insights into migraine attacks from neuroimaging
Lancet Neurol. 2023 Sep;22(9):834-846. doi: 10.1016/S1474-4422(23)00152-7.
Messina R, Rocca MA, Goadsby PJ, Filippi M.
Safety and tolerability of monoclonal antibodies targeting the CGRP pathway and gepants in migraine prevention: A systematic review and network meta-analysis
Cephalalgia. 2023 Mar;43(3):3331024231152169. doi: 10.1177/03331024231152169.
Messina R, Huessler EM, Puledda F, Haghdoost F, Lebedeva ER, Diener HC.