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Oreste Gentilini

Specialty:

Breast Cancer Breast Surgery

Profession:

Breast surgeon

Location:

Department of Breast Surgery @ Ospedale San Raffaele

Languages:

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Biography

Professor Oreste Davide Gentilini has been Head of the Breast Surgery Unit and Director of the Breast Unit at IRCCS Ospedale San Raffaele in Milan since 2015. He also collaborates with Casa di Cura La Madonnina and with the Policlinico San Marco in Bergamo.

He is also Associate Professor of General Surgery at Vita-Salute San Raffaele University in Milan.

He is a tenured lecturer in the degree programs of Medicine and Surgery, the International MD Program, the School of Specialization in General Surgery, and the Midwifery Degree Program at Vita-Salute San Raffaele University.

He is also a founding member and president of the international research organization EUBREAST.

He graduated in Medicine and Surgery in 1993 and specialized in General Surgery in 1999 at the University of Milan, both with honors. Since 2001 he has devoted his clinical and research activity to breast cancer after completing a research fellowship in the United States at the New York Hospital–Cornell Medical Center.

From 2000 to 2015 he worked at the European Institute of Oncology, where he eventually became Senior Vice Director of the Breast Division. For the same institute, he was also a member of the Scientific Review Board from 2014 to 2015.

He is responsible for research projects aimed at preserving the breast and axillary lymph nodes, even after neoadjuvant chemotherapy. He is an expert in familial and hereditary breast cancers and in preventive “risk-reduction” procedures in women at high genetic risk. He has personally performed more than 5,000 breast surgery procedures. He is the coordinator and principal investigator of the international multicenter SOUND trial on axillary staging in women with early breast cancer.

Since 2018 he has been a founding member, board member, and vice president of the international breast cancer research association EU-BREAST (EUropean Breast cancer REsearch Association of Surgical Trialists). Since 2019 he has been a member of the board of ANISC – the Italian National Association of Breast Surgeons.

Since 2012 he has been a member of the European expert panel on breast cancer in young women and during pregnancy. Dr. Gentilini is also a member of the Editorial Board of the European Journal of Surgical Oncology and since 2018 he has been a Specialty Editor of the journal The Breast (Impact Factor 3.4). He is the author of more than 100 international publications and has been an invited speaker at more than 100 national and international conferences.

Education

University of Milan
Degree in Medicine and Surgery – 1993

University of Milan
Specialization in General Surgery – 1999

Publications

Latest publications

Sentinel node biopsy after primary systemic therapy in node positive breast cancer patients: Time trend, imaging staging power and nodal downstaging according to molecular subtype.

Eur J Surg Oncol. 2019 Jun;45(6):969-975. doi: 10.1016/j.ejso.2019.01.219. Epub 2019 Jan 31. PMID: 30744944

Di Micco R, Zuber V, Fiacco E, Carriero F, Gattuso MI, Nazzaro L, Panizza P, Gianolli L, Canevari C, Di Muzio N, Pasetti M, Sassi I, Zambetti M, Gentilini OD.

A gap analysis of opportunities and priorities for breast surgical research.

Lancet Oncol. 2019 Jan;20(1):e1. doi: 10.1016/S1470-2045(18)30916-1. PMID:30614465

Gentilini OD, De Boniface J, Classe JM, Peintinger F, Reimer T, Reitsamer R, Rubio I, Smidt M, Kuehn T.

Oncoplastic Breast Consortium consensus conference on nipple-sparing mastectomy.

Breast Cancer Res Treat. 2018 Dec;172(3):523-537. doi: 10.1007/s10549-018-4937-1. Epub 2018 Sep 4. Review.

Weber WP, Haug M, Kurzeder C, Bjelic-Radisic V, Koller R, Reitsamer R, Fitzal F, Biazus J, Brenelli F, Urban C, Paulinelli RR, Blohmer JU, Heil J, Hoffmann J, Matrai Z, Catanuto G, Galimberti V, Gentilini O, Barry M, Hadar T, Allweis TM, Olsha O, Cardoso MJ, Gouveia PF, Rubio IT, de Boniface J, Svensjö T, Bucher S, Dubsky P, Farhadi J, Fehr MK, Fulco I, Ganz-Blättler U, Günthert A, Harder Y, Hauser N, Kappos EA, Knauer M, Landin J, Mechera R, Meani F, Montagna G, Ritter M, Saccilotto R, Schwab FD, Steffens D, Tausch C, Zeindler J, Soysal SD, Lohsiriwat V, Kovacs T, Tansley A, Wyld L, Romics L, El-Tamer M, Pusic AL, Sacchini V, Gnant M.

Is Axillary Sentinel Lymph Node Biopsy Required in Patients Who Undergo Primary Breast Surgery?

Breast Care (Basel). 2018 Oct;13(5):324-330. doi: 10.1159/000491703. Epub 2018 Aug 24. Review.

Reimer T, Engel J, Schmidt M, Offersen BV, Smidt ML, Gentilini OD.

Axillary staging for breast cancer during pregnancy: feasibility and safety of sentinel lymph node biopsy.

Breast Cancer Res Treat. 2018 Apr;168(2):551-557. doi: 10.1007/s10549-017-4611-z. Epub 2017 Dec 12. PMID:29235045

Han SN, Amant F, Cardonick EH, Loibl S, Peccatori FA, Gheysens O, Sangalli CA, Nekljudova V, Steffensen KD, Mhallem Gziri M, Schröder CP, Lok CAR, Verest A, Neven P, Smeets A, Pruneri G, Cremonesi M, Gentilini O; International Network on Cancer, Infertility and Pregnancy.

Sentinel node biopsy in early breast cancer. A review on recent and ongoing randomized trials.

Breast. 2017 Dec;36:14-19. doi: 10.1016/j.breast.2017.08.006. Epub 2017 Aug 29. Review.

Esposito E, Di Micco R, Gentilini OD.

ESO-ESMO 3rd international consensus guidelines for breast cancer in young women (BCY3).

Breast. 2017 Oct;35:203-217. doi: 10.1016/j.breast.2017.07.017. Epub 2017 Aug 17.

Paluch-Shimon S, Pagani O, Partridge AH, Abulkhair O, Cardoso MJ, Dent RA, Gelmon K, Gentilini O, Harbeck N, Margulies A, Meirow D, Pruneri G, Senkus E, Spanic T, Sutliff M, Travado L, Peccatori F, Cardoso F.

Less is more. Breast conservation might be even better than mastectomy in early breast cancer patients.

Breast. 2017 Oct;35:32-33. doi: 10.1016/j.breast.2017.06.004. Epub 2017 Jun 20. Review.

Gentilini OD, Cardoso MJ, Poortmans P.

Ipsilateral axillary recurrence after breast conservative surgery: The protective effect of whole breast radiotherapy.

Radiother Oncol. 2017 Jan;122(1):37-44. doi: 10.1016/j.radonc.2016.12.021. Epub 2017 Jan 4.

Gentilini O, Botteri E, Leonardi MC, Rotmensz N, Vila J, Peradze N, Thomazini MV, Jereczek BA, Galimberti V, Luini A, Veronesi P, Orecchia R.

Contralateral risk reducing mastectomy in patients with sporadic breast cancer. Benefits and hazards.

Eur J Surg Oncol. 2016 Jul;42(7):913-8. doi: 10.1016/j.ejso.2016.04.054. Epub 2016 May 3. Review. PMID: 27189832

Boccardo C, Gentilini O.

Staging the Axilla in Early Breast Cancer: Will Imaging Replace Surgery?

JAMA Oncol. 2015 Aug 20. doi: 10.1001/jamaoncol.2015.2337. [Epub ahead of print]. PMID: 26291922

Gentilini O, Veronesi U.

Overall survival according to type of surgery in young (≤40 years) early breast cancer patients: A systematic meta-analysis comparing breast-conserving surgery versus mastectomy.

Breast. 2015 Feb 23 [Epub ahead of print].

Vila J, Gandini S, Gentilini O.

Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial.

Lancet Oncol. 2013 Dec;14(13):1269-77. doi: 10.1016/S1470-2045(13)70497-2. Epub 2013 Nov 11.

Veronesi U, Orecchia R, Maisonneuve P, Viale G, Rotmensz N, Sangalli C, Luini A, Veronesi P, Galimberti V, Zurrida S, Leonardi MC, Lazzari R, Cattani F, Gentilini O, Intra M, Caldarella P, Ballardini B.

Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial.

Lancet Oncol. 2013 Apr;14(4):297-305. doi: 10.1016/S1470-2045(13)70035-4. Epub 2013 Mar 11. Erratum in: Lancet Oncol. 2013 Jun;14(7):e254.

Galimberti V, Cole BF, Zurrida S, Viale G, Luini A, Veronesi P, Baratella P, Chifu C, Sargenti M, Intra M, Gentilini O, Mastropasqua MG, Mazzarol G, Massarut S, Garbay JR, Zgajnar J, Galatius H, Recalcati A, Littlejohn D, Bamert M, Colleoni M, Price KN, Regan MM, Goldhirsch A, Coates AS, Gelber RD, Veronesi U; International Breast Cancer Study Group Trial 23-01 investigators.

Abandoning sentinel lymph node biopsy in early breast cancer? A new trial in progress at the European Institute of Oncology of Milan (SOUND: Sentinel node vs Observation after axillary UltraSouND).

Breast. 2012 Oct;21(5):678-81. doi: 10.1016/j.breast.2012.06.013. Epub 2012 Jul 25.

Gentilini O, Veronesi U.